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From streaming to healthcare to AI, Mark Cuban reveals his ‘disruption formula’

By Advanced AI EditorAugust 27, 2025No Comments2 Mins Read
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Steve Jobs once said, “Everything’s a remix.” And that’s a philosophy that Mark Cuban has taken to heart, building an entire entrepreneurial and investment career on that simple belief. The real opportunity, Cuban says, lies in spotting patterns others miss and turning them into billion-dollar disruptions.

On today’s episode of Equity, Cuban joined TechCrunch’s Rebecca Bellan to discuss his decades-long strategy of betting on technologies before they go mainstream, from his early investments in local area networks and streaming services to his current healthcare and AI ventures.

But Cuban’s real insight isn’t just about picking winners. It’s about understanding why most people building in AI today are missing the point entirely.

Cuban delivered a stark warning about the current AI gold rush: While everyone’s using ChatGPT, almost no one (including Fortune 500 CEOs) knows how to integrate AI into their actual businesses. His take? Forget the hype. The real money is in helping small- and medium-sized businesses figure out how to use the AI tools that already exist.

Listen to the full episode to hear:

How Cuban identified disruptive opportunities in LANs, streaming, and HD television before they became obvious.

Why he thinks current AI “isn’t smart,” and why that limitation could be its strength as a business tool.

The upcoming regulatory battles that will determine AI’s future around IP protection, training data access, and the U.S.-China competition.

Inside Cuban’s latest venture, Cost Plus Drugs, expanding from transparent pricing to manufacturing.

Cuban’s prediction that AI-savvy graduates will become the most in-demand employees across every industry.

As always, Equity will be back Friday. Don’t miss it!

Equity is TechCrunch’s flagship podcast, produced by Theresa Loconsolo, and posts every Wednesday and Friday. 

Subscribe to us on Apple Podcasts, Overcast, Spotify and all the casts. You also can follow Equity on X and Threads, at @EquityPod. 



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