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MIT Lincoln Laboratory deploys Nvidia-powered AI supercomputer

By Advanced AI EditorOctober 8, 2025No Comments2 Mins Read
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MIT Lincoln Laboratory has deployed an AI supercomputer at its Supercomputing Center in Holyoke, Massachusetts.

According to MIT, the system, dubbed TX-GAIN, is the most powerful AI-dedicated supercomputer deployed by a US university.

Powered by more than 600 Nvidia H100 GPUs, the system ranked 114 on the most recent edition of the Top500 list, achieving a HPL score of 13.39 petaflops, although the university claims it also has 2 exaflops of AI compute power.

MIT will use the supercomputer to support biodefense, materials discovery, and national security research. The data center where TX-GAIN is housed also supports collaborations with other MIT institutions, including the Haystack Observatory, the Center for Quantum Engineering, and the Air Force–MIT AI Accelerator.

“TX-GAIN will enable our researchers to achieve scientific and engineering breakthroughs,” said Jeremy Kepner, Lincoln Laboratory Fellow and head of the Supercomputing Center. “The system will play a large role in supporting generative AI, physical simulation, and data analysis across all research areas.”

Rafael Jaimes, a researcher in the Counter–Weapons of Mass Destruction Systems Group, added: “TX-GAIN is allowing us to model not only significantly more protein interactions than ever before, but also much larger proteins with more atoms. This new computational capability is a game-changer for protein characterization efforts in biological defense.”



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