HPE announced significant advancements to its NVIDIA AI Computing by HPE portfolio that supports enterprise customers of all sizes throughout the entire AI lifecycle.
These developments bolster integration with NVIDIA AI Enterprise and bring the newest NVIDIA AI models and NVIDIA Blueprints to HPE Private Cloud AI, enabling developers to deploy AI applications withease. HPE will also ship HPE ProLiant Compute servers that feature NVIDIA Blackwell accelerated computing to advance generative, agentic and physical AI workloads.
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These developments bolster integration with NVIDIA AI Enterprise and bring the newest NVIDIA AI models and NVIDIA Blueprints to HPE Private Cloud AI, enabling developers to deploy AI applications with ease.
HPE ProLiant Compute servers accelerated by NVIDIA RTX PRO 6000 Blackwell GPUs
HPE ProLiant Compute servers accelerated by the NVIDIA Blackwell architecture will be available time-to-market. This includes two NVIDIA RTX PRO Server configurations:
HPE ProLiant DL385 Gen11 server: Supporting up to two NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs in the new 2U RTX PRO Server form factor, this air-cooled server is well-suited for datacenters tasked with meeting the growing AI demands of the enterprise.
HPE ProLiant Compute DL380a Gen12 server: Supporting up to 8 NVIDIA RTX PRO 6000 GPUs in a 4U form factor, this previously announced configuration will ship in September.
Purpose-built to handle diverse workloads and meet growing enterprise IT demand for GPU-accelerated compute power, HPE ProLiant Compute servers provide organizations with the flexibility and power to innovate across the enterprise, helping unlock new levels of productivity, security, and operational efficiency. HPE ProLiant Compute Gen12 servers feature multi-layered security with HPE Integrated Lights Out (iLO) 7 Silicon Root of Trust and a secure enclave that enables tamper-resistant protection and quantum-resistant firmware signing. Centralized, cloud-native lifecycle automation delivered through HPE Compute Ops Management reduces IT hours spent on server management by up to 75% and downtime by 4.8 hours per server annuallyi. Target workloads include generative and agentic AI; along with physical AI, including robotics and industrial use cases; visual computing, such as quality control monitoring and autonomous vehicles; simulation; 3D modeling; digital twins; and enterprise applications.
HPE recently announced the next generation of HPE Private Cloud AI that will be available later this year. This includes support for NVIDIA RTX PRO 6000 GPUs with HPE ProLiant Compute Gen12 servers, seamless scalability across GPU generations, air-gapped management, and enterprise multi-tenancy.
HPE Private Cloud AI adds support for new NVIDIA reasoning models and video blueprint
HPE Private Cloud AI, a turnkey AI factory solution for the enterprise co-developed with NVIDIA, will support the latest versions of the NVIDIA Nemotron models for agentic AI, Cosmos Reason vision language model (VLM) for physical AI and robotics, and the NVIDIA Blueprint for Video Search and Summarization (VSS 2.4) to build video analytics AI agents that can extract valuable insights from massive columns of video data. Through continuous co-development between HPE and NVIDIA, HPE Private Cloud AI is uniquely designed to deliver the fastest deployment of NVIDIA NIM microservices for the latest AI models and NVIDIA Blueprints—accessible by customers through HPE AI Essentials.
Through the deepest integration with NVIDIA AI accelerated computing, networking, and software, HPE Private Cloud AI enables enterprises to harness the full potential of AI faster while maintaining control over their data. Customers can leverage this high-performance solution to manage the surging demand for AI inferencing and accelerate AI production.
Our collaboration with NVIDIA continues to push the boundaries of innovation, delivering solutions that unlock the value of generative, agentic and physical AI while addressing the unique demands of enterprise workloads.
Driving the AI Revolution Together
Availability
The HPE ProLiant DL385 Gen11 and HPE ProLiant Compute DL380a Gen12 servers featuring NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs are orderable today and will begin shipping worldwide September 2, 2025.
HPE Private Cloud AI support for NVIDIA Nemotron models, Cosmos Reason, and NVIDIA Blueprint for VSS 2.4 will be available during the second half of 2025.
The next generation of HPE Private Cloud AI with NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs will be released in the second half of 2025.
Cheri Williams, Senior Vice President and General Manager for private cloud and flex solutions at HPE
HPE is committed to empowering enterprises with the tools they need to succeed in the age of AI. Our collaboration with NVIDIA continues to push the boundaries of innovation, delivering solutions that unlock the value of generative, agentic and physical AI while addressing the unique demands of enterprise workloads. With the combination of HPE ProLiant servers and expanded capabilities in HPE Private Cloud AI, we’re enabling organizations to embrace the future of AI with confidence and agility.
Justin Boitano, Vice President of enterprise AI at NVIDIA
Enterprises need flexible, efficient infrastructure to keep pace with the demands of modern AI. With NVIDIA RTX PRO 6000 Blackwell GPUs in HPE’s 2U ProLiant servers, enterprises can accelerate virtually every workload on a single, unified, enterprise-ready platform.